Critical roles of the Cu(B) site in efficient proton pumping as revealed by crystal structures of mammalian cytochrome c oxidase catalytic intermediates

Mammalian cytochrome c oxidase (CcO) reduces O(2) to water in a bimetallic site including Fe(a3) and Cu(B) giving intermediate molecules, termed A-, P-, F-, O-, E-, and R-forms. From the P-form on, each reaction step is driven by single-electron donations from cytochrome c coupled with the pumping o...

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Detalles Bibliográficos
Autores principales: Shimada, Atsuhiro, Hara, Fumiyoshi, Shinzawa-Itoh, Kyoko, Kanehisa, Nobuko, Yamashita, Eiki, Muramoto, Kazumasa, Tsukihara, Tomitake, Yoshikawa, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390519/
https://www.ncbi.nlm.nih.gov/pubmed/34274318
http://dx.doi.org/10.1016/j.jbc.2021.100967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390519/
https://www.ncbi.nlm.nih.gov/pubmed/34274318
http://dx.doi.org/10.1016/j.jbc.2021.100967

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