The HIV-1 accessory protein Nef increases surface expression of the checkpoint receptor Tim-3 in infected CD4(+) T cells

Prolonged immune activation drives the upregulation of multiple checkpoint receptors on the surface of virus-specific T cells, inducing their exhaustion. Reversing HIV-1-induced T cell exhaustion is imperative for efficient virus clearance; however, viral mediators of checkpoint receptor upregulatio...

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Detalles Bibliográficos
Autores principales: Jacob, Rajesh Abraham, Edgar, Cassandra R., Prévost, Jérémie, Trothen, Steven M., Lurie, Antony, Mumby, Mitchell J., Galbraith, Alexa, Kirchhoff, Frank, Haeryfar, S.M. Mansour, Finzi, Andrés, Dikeakos, Jimmy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390549/
https://www.ncbi.nlm.nih.gov/pubmed/34358561
http://dx.doi.org/10.1016/j.jbc.2021.101042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390549/
https://www.ncbi.nlm.nih.gov/pubmed/34358561
http://dx.doi.org/10.1016/j.jbc.2021.101042

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