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TP53 isoform junction reads based analysis in malignant and normal contexts

TP53 is one of the most frequently altered genes in cancer; it can be inactivated by a number of different mechanisms. NM_000546.6 (ENST00000269305.9) is by far the predominant TP53 isoform, however a few other alternative isoforms have been described to be expressed at much lower levels. To better...

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Detalles Bibliográficos
Autores principales: Vural, Suleyman, Chang, Lun-Ching, Yee, Laura M., Sonkin, Dmitriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390641/
https://www.ncbi.nlm.nih.gov/pubmed/34446762
http://dx.doi.org/10.1038/s41598-021-96700-1