Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

Serial circulating tumor DNA (ctDNA) monitoring is emerging as a non-invasive strategy to predict and monitor immune checkpoint blockade (ICB) therapeutic efficacy across cancer types. Yet, limited data exist to show the relationship between ctDNA dynamics and tumor genome and immune microenvironmen...

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Detalles Bibliográficos
Autores principales: Cindy Yang, S. Y., Lien, Scott C., Wang, Ben X., Clouthier, Derek L., Hanna, Youstina, Cirlan, Iulia, Zhu, Kelsey, Bruce, Jeffrey P., El Ghamrasni, Samah, Iafolla, Marco A. J., Oliva, Marc, Hansen, Aaron R., Spreafico, Anna, Bedard, Philippe L., Lheureux, Stephanie, Razak, Albiruni, Speers, Vanessa, Berman, Hal K., Aleshin, Alexey, Haibe-Kains, Benjamin, Brooks, David G., McGaha, Tracy L., Butler, Marcus O., Bratman, Scott V., Ohashi, Pamela S., Siu, Lillian L., Pugh, Trevor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390680/
https://www.ncbi.nlm.nih.gov/pubmed/34446728
http://dx.doi.org/10.1038/s41467-021-25432-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390680/
https://www.ncbi.nlm.nih.gov/pubmed/34446728
http://dx.doi.org/10.1038/s41467-021-25432-7

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