Cargando…
Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular dementia
Cerebrovascular pathology at the biochemical level has been informed by the study of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a vascular disorder caused by NOTCH3 mutations. Previous work in CADASIL described N-terminal proteolysis of NOTC...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390697/ https://www.ncbi.nlm.nih.gov/pubmed/34446744 http://dx.doi.org/10.1038/s41598-021-96679-9 |