Downregulation of CD40L–CD40 attenuates seizure susceptibility and severity of seizures

Unregulated neuro-inflammation mediates seizures in temporal lobe epilepsy (TLE). Our aim was to determine the effect of CD40–CD40L activation in experimental seizures. CD40 deficient mice (CD40KO) and control mice (wild type, WT) received pentenyltetrazole (PTZ) or pilocarpine to evaluate seizures...

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Detalles Bibliográficos
Autores principales: Pototskiy, Esther, Vinokuroff, Katherine, Ojeda, Andrew, Major, C. Kendall, Sharma, Deepak, Anderson, Taylor, Howard, Kendall, Borenstein, Ronen, Musto, Alberto E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390750/
https://www.ncbi.nlm.nih.gov/pubmed/34446808
http://dx.doi.org/10.1038/s41598-021-96760-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390750/
https://www.ncbi.nlm.nih.gov/pubmed/34446808
http://dx.doi.org/10.1038/s41598-021-96760-3

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