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Geometry and water accessibility of the inhibitor binding site of Na(+)-pump: Pulse- and CW-EPR study

Spin labels based on cinobufagin, a specific inhibitor of the Na,K-ATPase, have proved valuable tools to characterize the binding site of cardiotonic steroids (CTSs), which also constitutes the extracellular cation pathway. Because existing literature suggests variations in the physiological respons...

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Detalles Bibliográficos
Autores principales: Aloi, Erika, Guo, Jin-Hua, Guzzi, Rita, Jiang, Ren-Wang, Ladefoged, Lucy Kate, Marsh, Derek, Esmann, Mikael, Bartucci, Rosa, Fedosova, Natalya U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390900/
https://www.ncbi.nlm.nih.gov/pubmed/34087213
http://dx.doi.org/10.1016/j.bpj.2021.05.018