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Geometry and water accessibility of the inhibitor binding site of Na(+)-pump: Pulse- and CW-EPR study
Spin labels based on cinobufagin, a specific inhibitor of the Na,K-ATPase, have proved valuable tools to characterize the binding site of cardiotonic steroids (CTSs), which also constitutes the extracellular cation pathway. Because existing literature suggests variations in the physiological respons...
Autores principales: | Aloi, Erika, Guo, Jin-Hua, Guzzi, Rita, Jiang, Ren-Wang, Ladefoged, Lucy Kate, Marsh, Derek, Esmann, Mikael, Bartucci, Rosa, Fedosova, Natalya U. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390900/ https://www.ncbi.nlm.nih.gov/pubmed/34087213 http://dx.doi.org/10.1016/j.bpj.2021.05.018 |
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