Allosteric regulation in CRISPR/Cas1-Cas2 protospacer acquisition mediated by DNA and Cas2

Cas1 and Cas2 are highly conserved proteins across clustered-regularly-interspaced-short-palindromic-repeat-Cas systems and play a significant role in protospacer acquisition. Based on crystal structure of twofold symmetric Cas1-Cas2 in complex with dual-forked protospacer DNA (psDNA), we conducted...

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Detalles Bibliográficos
Autores principales: Long, Chunhong, Dai, Liqiang, E, Chao, Da, Lin-Tai, Yu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390960/
https://www.ncbi.nlm.nih.gov/pubmed/34197800
http://dx.doi.org/10.1016/j.bpj.2021.06.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390960/
https://www.ncbi.nlm.nih.gov/pubmed/34197800
http://dx.doi.org/10.1016/j.bpj.2021.06.007

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