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Spatially resolved free-energy contributions of native fold and molten-globule-like Crambin
The folding stability of a protein is governed by the free-energy difference between its folded and unfolded states, which results from a delicate balance of much larger but almost compensating enthalpic and entropic contributions. The balance can therefore easily be shifted by an external disturban...
Autores principales: | Heinz, Leonard P., Grubmüller, Helmut |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391029/ https://www.ncbi.nlm.nih.gov/pubmed/34087209 http://dx.doi.org/10.1016/j.bpj.2021.05.019 |
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