Effect of Pterostilbene, a Natural Derivative of Resveratrol, in the Treatment of Colorectal Cancer through Top1/Tdp1-Mediated DNA Repair Pathway

SIMPLE SUMMARY: Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs the stalled Topoisomerase 1 (Top1)-DNA covalent complex. It is conceivable that Tdp1 inhibitors could act synergistically with Top1 inhibitors to enhance the effect of Top1 poisons. This study identified pterostilbene (PTE) and resveratr...

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Detalles Bibliográficos
Autores principales: Zhang, Yutian, Li, Ying, Sun, Changcheng, Chen, Xiang, Han, Luyao, Wang, Tingqiang, Liu, Jinfeng, Chen, Xijing, Zhao, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391236/
https://www.ncbi.nlm.nih.gov/pubmed/34439157
http://dx.doi.org/10.3390/cancers13164002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391236/
https://www.ncbi.nlm.nih.gov/pubmed/34439157
http://dx.doi.org/10.3390/cancers13164002

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