Biological Functions of the Intrinsically Disordered N-Terminal Domain of the Prion Protein: A Possible Role of Liquid–Liquid Phase Separation

The mammalian prion protein (PrP(C)) is composed of a large intrinsically disordered N-terminal and a structured C-terminal domain, containing three alpha-helical regions and a short, two-stranded beta-sheet. Traditionally, the activity of a protein was linked to the ability of the polypeptide chain...

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Detalles Bibliográficos
Autores principales: Polido, Stella A., Kamps, Janine, Tatzelt, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391301/
https://www.ncbi.nlm.nih.gov/pubmed/34439867
http://dx.doi.org/10.3390/biom11081201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391301/
https://www.ncbi.nlm.nih.gov/pubmed/34439867
http://dx.doi.org/10.3390/biom11081201

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