Oleuropein Activates Neonatal Neocortical Proteasomes, but Proteasome Gene Targeting by AAV9 Is Variable in a Clinically Relevant Piglet Model of Brain Hypoxia-Ischemia and Hypothermia

Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasome activity differs regionally and developmentally in the neon...

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Detalles Bibliográficos
Autores principales: El Demerdash, Nagat, Chen, May W., O’Brien, Caitlin E., Adams, Shawn, Kulikowicz, Ewa, Martin, Lee J., Lee, Jennifer K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391411/
https://www.ncbi.nlm.nih.gov/pubmed/34440889
http://dx.doi.org/10.3390/cells10082120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391411/
https://www.ncbi.nlm.nih.gov/pubmed/34440889
http://dx.doi.org/10.3390/cells10082120

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