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Oleuropein Activates Neonatal Neocortical Proteasomes, but Proteasome Gene Targeting by AAV9 Is Variable in a Clinically Relevant Piglet Model of Brain Hypoxia-Ischemia and Hypothermia

Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasome activity differs regionally and developmentally in the neon...

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Detalles Bibliográficos
Autores principales:	El Demerdash, Nagat, Chen, May W., O’Brien, Caitlin E., Adams, Shawn, Kulikowicz, Ewa, Martin, Lee J., Lee, Jennifer K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391411/ https://www.ncbi.nlm.nih.gov/pubmed/34440889 http://dx.doi.org/10.3390/cells10082120

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