Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation

Amyloid precursor protein (APP), upon proteolytic degradation, forms aggregates of amyloid β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer’s disease (AD). Cathepsin B is a cysteine protease enzyme that catalyzes the proteolytic degradation of APP in the brain. Thus, ca...

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Detalles Bibliográficos
Autores principales: Chitranshi, Nitin, Kumar, Ashutosh, Sheriff, Samran, Gupta, Veer, Godinez, Angela, Saks, Danit, Sarkar, Soumalya, Shen, Ting, Mirzaei, Mehdi, Basavarajappa, Devaraj, Abyadeh, Morteza, Singh, Sachin K., Dua, Kamal, Zhang, Kam Y. J., Graham, Stuart L., Gupta, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391575/
https://www.ncbi.nlm.nih.gov/pubmed/34440715
http://dx.doi.org/10.3390/cells10081946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391575/
https://www.ncbi.nlm.nih.gov/pubmed/34440715
http://dx.doi.org/10.3390/cells10081946

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