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β-Adrenergic Stimulation Synchronizes a Broad Spectrum of Action Potential Firing Rates of Cardiac Pacemaker Cells toward a Higher Population Average
The heartbeat is initiated by pacemaker cells residing in the sinoatrial node (SAN). SAN cells generate spontaneous action potentials (APs), i.e., normal automaticity. The sympathetic nervous system increases the heart rate commensurate with the cardiac output demand via stimulation of SAN β-adrener...
Autores principales: | Kim, Mary S., Monfredi, Oliver, Maltseva, Larissa A., Lakatta, Edward G., Maltsev, Victor A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391682/ https://www.ncbi.nlm.nih.gov/pubmed/34440893 http://dx.doi.org/10.3390/cells10082124 |
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