Transcriptional Regulation of MECP2E1-E2 Isoforms and BDNF by Metformin and Simvastatin through Analyzing Nascent RNA Synthesis in a Human Brain Cell Line

Methyl CpG binding protein 2 (MeCP2) is the main DNA methyl-binding protein in the brain that binds to 5-methylcytosine and 5-hydroxymethyl cytosine. MECP2 gene mutations are the main origin of Rett Syndrome (RTT), a neurodevelopmental disorder in young females. The disease has no existing cure, how...

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Detalles Bibliográficos
Autores principales: Buist, Marjorie, Fuss, David, Rastegar, Mojgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391797/
https://www.ncbi.nlm.nih.gov/pubmed/34439919
http://dx.doi.org/10.3390/biom11081253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391797/
https://www.ncbi.nlm.nih.gov/pubmed/34439919
http://dx.doi.org/10.3390/biom11081253

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