Tissue-Nonspecific Alkaline Phosphatase (TNAP) as the Enzyme Involved in the Degradation of Nucleotide Analogues in the Ligand Docking and Molecular Dynamics Approaches

Tissue-nonspecific alkaline phosphatase (TNAP) is known to be involved in the degradation of extracellular ATP via the hydrolysis of pyrophosphate (PPi). We investigated, using three different computational methods, namely molecular docking, thermodynamic integration (TI) and conventional molecular...

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Detalles Bibliográficos
Autores principales: Madaj, Rafal, Gostynski, Bartlomiej, Pawlowska, Roza, Chworos, Arkadiusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391816/
https://www.ncbi.nlm.nih.gov/pubmed/34439771
http://dx.doi.org/10.3390/biom11081104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391816/
https://www.ncbi.nlm.nih.gov/pubmed/34439771
http://dx.doi.org/10.3390/biom11081104

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