Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain

SIMPLE SUMMARY: We evaluated the contribution of macrophages to the effect of combinatorial immunotherapeutic treatments based on TLR9 stimulation (with CpG-ODNs) and PD-1 blockade in an ovarian cancer preclinical model. We observed a strong reduction in the antitumor efficacy of a TLR9 agonist upon...

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Detalles Bibliográficos
Autores principales: Camelliti, Simone, Le Noci, Valentino, Bianchi, Francesca, Storti, Chiara, Arnaboldi, Francesca, Cataldo, Alessandra, Indino, Serena, Jachetti, Elena, Figini, Mariangela, Colombo, Mario Paolo, Balsari, Andrea, Gagliano, Nicoletta, Tagliabue, Elda, Sfondrini, Lucia, Sommariva, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391891/
https://www.ncbi.nlm.nih.gov/pubmed/34439233
http://dx.doi.org/10.3390/cancers13164081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391891/
https://www.ncbi.nlm.nih.gov/pubmed/34439233
http://dx.doi.org/10.3390/cancers13164081

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