Hot Spot Analysis of YAP-TEAD Protein-Protein Interaction Using the Fragment Molecular Orbital Method and Its Application for Inhibitor Discovery

SIMPLE SUMMARY: YAP-TEAD protein-protein interaction is a crucial feature in the Hippo pathway for cancer therapeutics. In this study, to investigate novel YAP-TEAD protein-protein interaction inhibitors, the fragment molecular orbital method for hot spot analysis of YAP-TEAD PPI and FMO-based pharm...

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Detalles Bibliográficos
Autores principales: Kim, Jongwan, Lim, Hocheol, Moon, Sungho, Cho, Seon Yeon, Kim, Minhye, Park, Jae Hyung, Park, Hyun Woo, No, Kyoung Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391968/
https://www.ncbi.nlm.nih.gov/pubmed/34439400
http://dx.doi.org/10.3390/cancers13164246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391968/
https://www.ncbi.nlm.nih.gov/pubmed/34439400
http://dx.doi.org/10.3390/cancers13164246

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