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Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
The 140 amino acid protein α-synuclein (αS) is an intrinsically disordered protein (IDP) with various roles and locations in healthy neurons that plays a key role in Parkinson’s disease (PD). Contact with biomembranes can lead to α-helical conformations, but can also act as s seeding event for aggre...
Autores principales: | Scheibe, Christian, Karreman, Christiaan, Schildknecht, Stefan, Leist, Marcel, Hauser, Karin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392020/ https://www.ncbi.nlm.nih.gov/pubmed/34439733 http://dx.doi.org/10.3390/biom11081067 |
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