The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress

We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed the...

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Detalles Bibliográficos
Autores principales: Ferreira Junior, Nilson Carlos, dos Santos Pereira, Maurício, Francis, Nour, Ramirez, Paola, Martorell, Paula, González-Lizarraga, Florencia, Figadère, Bruno, Chehin, Rosana, Del Bel, Elaine, Raisman-Vozari, Rita, Michel, Patrick Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392055/
https://www.ncbi.nlm.nih.gov/pubmed/34440932
http://dx.doi.org/10.3390/cells10082163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392055/
https://www.ncbi.nlm.nih.gov/pubmed/34440932
http://dx.doi.org/10.3390/cells10082163

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