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Interleukin-30 Suppresses Not Only CD4(+) T Cells but Also Regulatory T Cells in Murine Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is a chronic liver autoimmune disease with augmented T helper (Th) 1 and corresponding cytokine IFN-γ immune responses. Using 2-octynoic acid (2-OA) coupled to OVA (2-OA-OVA)-induced mouse models of autoimmune cholangitis (inducible chemical xenobiotic models of PBC...

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Detalles Bibliográficos
Autores principales: Chen, Hung-Wen, Lin, Chia-I., Chuang, Ya-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392158/
https://www.ncbi.nlm.nih.gov/pubmed/34440235
http://dx.doi.org/10.3390/biomedicines9081031