Severe Hepatic Insulin Resistance Induces Vascular Dysfunction: Improvement by Liver-Specific Insulin Receptor Isoform A Gene Therapy in a Murine Diabetic Model

Background: Cardiovascular dysfunction is linked to insulin-resistant states. In this paper, we analyzed whether the severe hepatic insulin resistance of an inducible liver-specific insulin receptor knockout (iLIRKO) might generate vascular insulin resistance and dysfunction, and whether insulin rec...

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Detalles Bibliográficos
Autores principales: Gómez-Hernández, Almudena, de las Heras, Natalia, López-Pastor, Andrea R., García-Gómez, Gema, Infante-Menéndez, Jorge, González-López, Paula, González-Illanes, Tamara, Lahera, Vicente, Benito, Manuel, Escribano, Óscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392327/
https://www.ncbi.nlm.nih.gov/pubmed/34440804
http://dx.doi.org/10.3390/cells10082035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392327/
https://www.ncbi.nlm.nih.gov/pubmed/34440804
http://dx.doi.org/10.3390/cells10082035

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