Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes

2,4-Dinitrophenol (DNP) is a classic uncoupler of oxidative phosphorylation in mitochondria which is still used in “diet pills”, despite its high toxicity and lack of antidotes. DNP increases the proton current through pure lipid membranes, similar to other chemical uncouplers. However, the molecula...

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Detalles Bibliográficos
Autores principales: Žuna, Kristina, Jovanović, Olga, Khailova, Ljudmila S., Škulj, Sanja, Brkljača, Zlatko, Kreiter, Jürgen, Kotova, Elena A., Vazdar, Mario, Antonenko, Yuri N., Pohl, Elena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392417/
https://www.ncbi.nlm.nih.gov/pubmed/34439844
http://dx.doi.org/10.3390/biom11081178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392417/
https://www.ncbi.nlm.nih.gov/pubmed/34439844
http://dx.doi.org/10.3390/biom11081178

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