Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids

[Image: see text] The arimetamycin A glycan governs the compound’s cytotoxicity (IC(50)). To study this branched, deoxy-amino disaccharide, we designed and synthesized a modified acyl donor that underwent glycosylation with three anthracycline aglycones: steffimycinone, daunorubicinone, and doxorubi...

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Detalles Bibliográficos
Autores principales: Huseman, Eric D., Byl, Jo Ann W., Chapp, Scott M., Schley, Nathan D., Osheroff, Neil, Townsend, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393218/
https://www.ncbi.nlm.nih.gov/pubmed/34471677
http://dx.doi.org/10.1021/acscentsci.1c00040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393218/
https://www.ncbi.nlm.nih.gov/pubmed/34471677
http://dx.doi.org/10.1021/acscentsci.1c00040

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