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Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids
[Image: see text] The arimetamycin A glycan governs the compound’s cytotoxicity (IC(50)). To study this branched, deoxy-amino disaccharide, we designed and synthesized a modified acyl donor that underwent glycosylation with three anthracycline aglycones: steffimycinone, daunorubicinone, and doxorubi...
Autores principales: | Huseman, Eric D., Byl, Jo Ann W., Chapp, Scott M., Schley, Nathan D., Osheroff, Neil, Townsend, Steven D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393218/ https://www.ncbi.nlm.nih.gov/pubmed/34471677 http://dx.doi.org/10.1021/acscentsci.1c00040 |
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