Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutières Syndrome and Singleton–Merten Syndrome

Melanoma differentiation-associated protein 5 (MDA5) is a crucial RIG-I-like receptor RNA helicase enzyme encoded by IFIH1 in humans. Single nucleotide polymorphisms in the IFIH1 results in fatal genetic disorders such as Aicardi–Goutières syndrome and Singleton–Merten syndrome, and in increased ris...

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Detalles Bibliográficos
Autores principales: Gosu, Vijayakumar, Sasidharan, Santanu, Saudagar, Prakash, Lee, Hak-Kyo, Shin, Donghyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393256/
https://www.ncbi.nlm.nih.gov/pubmed/34439917
http://dx.doi.org/10.3390/biom11081251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393256/
https://www.ncbi.nlm.nih.gov/pubmed/34439917
http://dx.doi.org/10.3390/biom11081251

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