The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis

Systemic sclerosis (SSc) is an autoimmune connective tissue disease that leads to skin fibrosis. Altered metabolism has recently been described in autoimmune diseases and SSc. Itaconate is a product of the Krebs cycle intermediate cis-aconitate and is an immunomodulator. This work examines the role...

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Detalles Bibliográficos
Autores principales: Henderson, John, Dayalan Naidu, Sharadha, Dinkova-Kostova, Albena T., Przyborski, Stefan, Stratton, Richard, O′Reilly, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393335/
https://www.ncbi.nlm.nih.gov/pubmed/34440821
http://dx.doi.org/10.3390/cells10082053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393335/
https://www.ncbi.nlm.nih.gov/pubmed/34440821
http://dx.doi.org/10.3390/cells10082053

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