Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2

SIMPLE SUMMARY: The mitochondrial enzyme serine hydroxymethyltransferase (SHMT2), which converts serine into glycine and generates 1C units for cell growth, is one of the most consistently overexpressed metabolic enzymes in cancer. Here, we reveal that the anti-diabetic biguanide metformin operates...

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Detalles Bibliográficos
Autores principales: Tramonti, Angela, Cuyàs, Elisabet, Encinar, José Antonio, Pietzke, Matthias, Paone, Alessio, Verdura, Sara, Arbusà, Aina, Martin-Castillo, Begoña, Giardina, Giorgio, Joven, Jorge, Vazquez, Alexei, Contestabile, Roberto, Cutruzzolà, Francesca, Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393646/
https://www.ncbi.nlm.nih.gov/pubmed/34439169
http://dx.doi.org/10.3390/cancers13164009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393646/
https://www.ncbi.nlm.nih.gov/pubmed/34439169
http://dx.doi.org/10.3390/cancers13164009

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