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BRIE2: computational identification of splicing phenotypes from single-cell transcriptomic experiments

RNA splicing is an important driver of heterogeneity in single cells through the expression of alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic coverage limitations of scRNA-seq technologies make it challenging to associate specific splicing events to...

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Detalles Bibliográficos
Autores principales: Huang, Yuanhua, Sanguinetti, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393734/
https://www.ncbi.nlm.nih.gov/pubmed/34452629
http://dx.doi.org/10.1186/s13059-021-02461-5