The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy

Translation initiation factor 2B (eIF2B) is a master regulator of global protein synthesis in all cell types. The mild genetic Eif2b5(R132H) mutation causes a slight reduction in eIF2B enzymatic activity which leads to abnormal composition of mitochondrial electron transfer chain complexes and impai...

Descripción completa

Detalles Bibliográficos
Autores principales: Herrero, Melisa, Daw, Maron, Atzmon, Andrea, Elroy-Stein, Orna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393801/
https://www.ncbi.nlm.nih.gov/pubmed/34440627
http://dx.doi.org/10.3390/cells10081858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393801/
https://www.ncbi.nlm.nih.gov/pubmed/34440627
http://dx.doi.org/10.3390/cells10081858

Ejemplares similares