A Leptin Receptor Antagonist Attenuates Adipose Tissue Browning and Muscle Wasting in Infantile Nephropathic Cystinosis-Associated Cachexia

Mice lacking the functional cystinosin gene (Ctns(−/−)), a model of infantile nephropathic cystinosis (INC), exhibit the cachexia phenotype with adipose tissue browning and muscle wasting. Elevated leptin signaling is an important cause of chronic kidney disease-associated cachexia. The pegylated le...

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Detalles Bibliográficos
Autores principales: Gonzalez, Alex, Cheung, Wai W., Perens, Elliot A., Oliveira, Eduardo A., Gertler, Arieh, Mak, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393983/
https://www.ncbi.nlm.nih.gov/pubmed/34440723
http://dx.doi.org/10.3390/cells10081954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393983/
https://www.ncbi.nlm.nih.gov/pubmed/34440723
http://dx.doi.org/10.3390/cells10081954

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