Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Background: Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD. Aims: Ten hydroxylated monocarbonyl curcumin derivatives were desig...

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Detalles Bibliográficos
Autores principales: Matiadis, Dimitris, Ng, See-Ting, Chen, Eric H.-L., Nigianni, Georgia, Vidali, Veroniki P., Canko, Aleksander, Chen, Rita P.-Y., Sagnou, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394082/
https://www.ncbi.nlm.nih.gov/pubmed/34440159
http://dx.doi.org/10.3390/biomedicines9080955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394082/
https://www.ncbi.nlm.nih.gov/pubmed/34440159
http://dx.doi.org/10.3390/biomedicines9080955

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