Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Upregulation of hydrogen sulfide (H(2)S) biosynthesis, at least in part related to the upregulation of cystathionine β-synthetase (CBS) in cancer cells, serves as a tumor-promoting factor and has emerged as a possible molecular target for antitumor drug development. To facilitate future clinical tra...

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Detalles Bibliográficos
Autores principales: Hellmich, Mark R., Chao, Celia, Módis, Katalin, Ding, Ye, Zatarain, John R., Thanki, Ketan, Maskey, Manjit, Druzhyna, Nadiya, Untereiner, Ashley A., Ahmad, Akbar, Xue, Yu, Chen, Haiying, Russell, William K., Wang, Jianmei, Zhou, Jia, Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394431/
https://www.ncbi.nlm.nih.gov/pubmed/34439739
http://dx.doi.org/10.3390/biom11081073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394431/
https://www.ncbi.nlm.nih.gov/pubmed/34439739
http://dx.doi.org/10.3390/biom11081073

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