Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models

The oxidative-stress-induced impairment of autophagy plays a critical role in the pathogenesis of Parkinson’s disease (PD). In this study, we investigated whether the alteration of Nrf2 in astrocytes protected against 6-OHDA (6-hydroxydopamine)- and rotenone-induced PD-like phenotypes, using 6-OHDA-...

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Detalles Bibliográficos
Autores principales: Guo, Qing, Wang, Bing, Wang, Xiaobo, Smith, Wanli W., Zhu, Yi, Liu, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394528/
https://www.ncbi.nlm.nih.gov/pubmed/34440619
http://dx.doi.org/10.3390/cells10081850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394528/
https://www.ncbi.nlm.nih.gov/pubmed/34440619
http://dx.doi.org/10.3390/cells10081850

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