RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

Ferroportin (FPN), the body’s sole iron exporter, is essential for maintaining systemic iron homeostasis. In response to either increased iron or inflammation, hepatocyte-secreted hepcidin binds to FPN, inducing its internalization and subsequent degradation. However, the E3 ubiquitin ligase that un...

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Detalles Bibliográficos
Autores principales: Jiang, Li, Wang, Jiaming, Wang, Kai, Wang, Hao, Wu, Qian, Yang, Cong, Yu, Yingying, Ni, Pu, Zhong, Yueyang, Song, Zijun, Xie, Enjun, Hu, Ronggui, Min, Junxia, Wang, Fudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394904/
https://www.ncbi.nlm.nih.gov/pubmed/33895792
http://dx.doi.org/10.1182/blood.2020008986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394904/
https://www.ncbi.nlm.nih.gov/pubmed/33895792
http://dx.doi.org/10.1182/blood.2020008986

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