Cargando…

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

Ferroportin (FPN), the body’s sole iron exporter, is essential for maintaining systemic iron homeostasis. In response to either increased iron or inflammation, hepatocyte-secreted hepcidin binds to FPN, inducing its internalization and subsequent degradation. However, the E3 ubiquitin ligase that un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Li, Wang, Jiaming, Wang, Kai, Wang, Hao, Wu, Qian, Yang, Cong, Yu, Yingying, Ni, Pu, Zhong, Yueyang, Song, Zijun, Xie, Enjun, Hu, Ronggui, Min, Junxia, Wang, Fudi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2021
Materias:	Red Cells, Iron, and Erythropoiesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394904/ https://www.ncbi.nlm.nih.gov/pubmed/33895792 http://dx.doi.org/10.1182/blood.2020008986

Ejemplares similares

The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease
por: Nyffenegger, Naja, et al.
Publicado: (2022)

Iron homeostasis governs erythroid phenotype in polycythemia vera
por: Bennett, Cavan, et al.
Publicado: (2023)

Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions
por: Myers, Greggory, et al.
Publicado: (2023)

Membrane bending and sphingomyelinase-associated, sulfatide-dependent hypoxic adhesion of sickle mature erythrocytes
por: Goreke, Utku, et al.
Publicado: (2023)

Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation
por: Courbon, Guillaume, et al.
Publicado: (2023)

Health-related quality of life and fatigue in children and adults with pyruvate kinase deficiency
por: Al-Samkari, Hanny, et al.
Publicado: (2022)

A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia
por: Yu, Lei, et al.
Publicado: (2021)

Restriction of HIV-1 infection in sickle cell trait
por: Kumari, Namita, et al.
Publicado: (2021)

Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis
por: Narla, Anupama, et al.
Publicado: (2011)

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
por: Prentice, Andrew M., et al.
Publicado: (2012)

A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax
por: Russell, Bruce, et al.
Publicado: (2011)

Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleation
por: An, Chao, et al.
Publicado: (2021)

Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice
por: Selma, Jada, et al.
Publicado: (2022)

CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles
por: Yanatori, Izumi, et al.
Publicado: (2021)

ABCB6 polymorphisms are not overly represented in patients with porphyria
por: Farrell, Colin P., et al.
Publicado: (2022)

Azacitidine is a potential therapeutic drug for pyridoxine-refractory female X-linked sideroblastic anemia
por: Morimoto, Yuki, et al.
Publicado: (2022)

Regulatory association of long noncoding RNAs and chromatin accessibility facilitates erythroid differentiation
por: Ren, Yunxiao, et al.
Publicado: (2021)

The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors
por: Marcero, Jason R., et al.
Publicado: (2021)

A community-centered approach to sickle cell disease and clinical trial participation: an evaluation of perceptions, facilitators, and barriers
por: Lee, LaTasha H., et al.
Publicado: (2021)

Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice
por: Woloshun, Regina R., et al.
Publicado: (2022)

Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation
por: Nemkov, Travis, et al.
Publicado: (2022)

Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion
por: de Bruin, Sanne, et al.
Publicado: (2022)

Elucidating parasite and host-cell factors enabling Babesia infection in sickle red cells under hypoxic/hyperoxic conditions
por: Beri, Divya, et al.
Publicado: (2022)

ATG4A regulates human erythroid maturation and mitochondrial clearance
por: Stolla, Massiel Chavez, et al.
Publicado: (2022)

A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection
por: Zhang, Vida, et al.
Publicado: (2022)

RNA-regulatory exosome complex suppresses an apoptotic program to confer erythroid progenitor cell survival in vivo
por: Fraga de Andrade, Isabela, et al.
Publicado: (2022)

Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept
por: Hertz, Laura, et al.
Publicado: (2022)

Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton
por: Szpak, Dorota, et al.
Publicado: (2023)

Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia
por: Clayden, Jonathan D., et al.
Publicado: (2022)

Simultaneous adjunctive treatment of malaria and its coevolved genetic disorder sickle cell anemia
por: Safeukui, Innocent, et al.
Publicado: (2023)

Computer vision quantitation of erythrocyte shape abnormalities provides diagnostic, prognostic, and mechanistic insight
por: Foy, Brody H., et al.
Publicado: (2023)

The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution
por: Doty, Raymond T., et al.
Publicado: (2023)

Genome-wide meta-analysis identifies new candidate genes for sickle cell disease nephropathy
por: Garrett, Melanie E., et al.
Publicado: (2022)

Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects
por: Cloos, Anne-Sophie, et al.
Publicado: (2023)

Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function
por: Zhou, Yichao, et al.
Publicado: (2023)

Autoimmune hemolytic anemia during pregnancy and puerperium: an international multicenter experience
por: Fattizzo, Bruno, et al.
Publicado: (2023)

Duodenal macrophages control dietary iron absorption via local degradation of transferrin
por: Sukhbaatar, Nyamdelger, et al.
Publicado: (2023)

Plasmodium falciparum infection of human erythroblasts induces transcriptional changes associated with dyserythropoiesis
por: Feldman, Tamar P., et al.
Publicado: (2023)

Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
por: Li, Xiuqi, et al.
Publicado: (2023)

Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF
por: Ibanez, Vinzon, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kr9ltm7mt6pq19b746k3p6ftig