Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death

Vps35 (vacuolar protein sorting 35) is a key component of retromer that consists of Vps35, Vps26, and Vps29 trimers, and sortin nexin dimers. Dysfunctional Vps35/retromer is believed to be a risk factor for development of various neurodegenerative diseases. Vps35(Neurod6) mice, which selectively kno...

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Detalles Bibliográficos
Autores principales: Zhao, Yang, Tang, Fulei, Lee, Daehoon, Xiong, Wen-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395035/
https://www.ncbi.nlm.nih.gov/pubmed/34445101
http://dx.doi.org/10.3390/ijms22168394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395035/
https://www.ncbi.nlm.nih.gov/pubmed/34445101
http://dx.doi.org/10.3390/ijms22168394

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