Effect of L- to D-Amino Acid Substitution on Stability and Activity of Antitumor Peptide RDP215 against Human Melanoma and Glioblastoma

The study investigates the antitumor effect of two cationic peptides, R-DIM-P-LF11-215 (RDP215) and the D-amino acid variant 9D-R-DIM-P-LF11-215 (9D-RDP215), targeting the negatively charged lipid phosphatidylserine (PS) exposed by cancer cells, such as of melanoma and glioblastoma. Model studies mi...

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Detalles Bibliográficos
Autores principales: Maxian, Theresa, Gerlitz, Lisa, Riedl, Sabrina, Rinner, Beate, Zweytick, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395111/
https://www.ncbi.nlm.nih.gov/pubmed/34445175
http://dx.doi.org/10.3390/ijms22168469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395111/
https://www.ncbi.nlm.nih.gov/pubmed/34445175
http://dx.doi.org/10.3390/ijms22168469

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