Cargando…

Integrin αv and Vitronectin Prime Macrophage-Related Inflammation and Contribute the Development of Dry Eye Disease

Cell signaling mediated by the αv integrin plays a pivotal role in macrophage activation in various inflammatory processes, but its involvement in the pathogenesis of dry eye disease (DED) remains unclear. In a murine model of DED, we found increased αv integrin expression in ocular surface macropha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Tsung-Chuan, Yeh, Shu-I, Chen, Show-Li, Tsao, Yeou-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395123/ https://www.ncbi.nlm.nih.gov/pubmed/34445121 http://dx.doi.org/10.3390/ijms22168410

Ejemplares similares

The Therapeutic Effects of a PEDF-Derived Short Peptide on Murine Experimental Dry Eye Involves Suppression of MMP-9 and Inflammation
por: Ho, Tsung-Chuan, et al.
Publicado: (2022)

The Psoriasis Therapeutic Potential of a Novel Short Laminin Peptide C16
por: Ho, Tsung-Chuan, et al.
Publicado: (2019)

A short peptide derived from pigment epithelial-derived factor exhibits an angioinhibitory effect
por: Ho, Tsung-Chuan, et al.
Publicado: (2022)

Expression of alphav integrins and vitronectin receptor identity in breast cancer cells.
por: Meyer, T., et al.
Publicado: (1998)

Pigment Epithelium Derived Factor Peptide Protects Murine Hepatocytes from Carbon Tetrachloride-Induced Injury
por: Shih, Shou-Chuan, et al.
Publicado: (2016)

Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding
Publicado: (1996)

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating b2 integrin clustering
por: Zuchtriegel, Gabriele, et al.
Publicado: (2020)

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen
Publicado: (1992)

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier
por: Ayloo, Swathi, et al.
Publicado: (2022)

Vitronectin‐activated αvβ3 and αvβ5 integrin signalling specifies haematopoietic fate in human pluripotent stem cells
por: Shen, Jun, et al.
Publicado: (2021)

Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface
Publicado: (1991)

Glycation of vitronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2–αvβ3 integrin cross-talk
por: Wang, L, et al.
Publicado: (2015)

Vitronectin in human hepatic tumours contributes to the recruitment of lymphocytes in an αvβ3-independent manner
por: Edwards, S, et al.
Publicado: (2006)

A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin
Publicado: (1993)

Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins
por: Welser-Alves, Jennifer V, et al.
Publicado: (2011)

Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells
por: Cheng, Huey-Chuan, et al.
Publicado: (2008)

Adhesion of a chicken myeloblast cell line to fibrinogen and vitronectin through a beta 1-class integrin
Publicado: (1992)

Interleukin-20 is involved in dry eye disease and is a potential therapeutic target
por: Wang, Hsiao-Hsuan, et al.
Publicado: (2022)

Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line
por: Yang, Yuh-Cheng, et al.
Publicado: (2007)

PEDF-derived peptide promotes tendon regeneration through its mitogenic effect on tendon stem/progenitor cells
por: Ho, Tsung-Chuan, et al.
Publicado: (2019)

Macrophage promotes fibroblast activation and kidney fibrosis by assembling a vitronectin-enriched microenvironment
por: Peng, Yiling, et al.
Publicado: (2023)

Receptor tyrosine kinase signaling required for integrin alpha v beta 5- directed cell motility but not adhesion on vitronectin
Publicado: (1994)

Functional role of vitronectin in breast cancer
por: Bera, Alakesh, et al.
Publicado: (2020)

Pigment Epithelium-Derived Factor 34-mer Peptide Prevents Liver Fibrosis and Hepatic Stellate Cell Activation through Down-Regulation of the PDGF Receptor
por: Tsai, Tung-Han, et al.
Publicado: (2014)

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells
Publicado: (1991)

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
por: Perry, V. Hugh, et al.
Publicado: (2013)

Interaction of Late Apoptotic and Necrotic Cells with Vitronectin
por: Stepanek, Ondrej, et al.
Publicado: (2011)

Vitronectin promotes immunothrombotic dysregulation in the venular microvasculature
por: Uhl, Bernd, et al.
Publicado: (2023)

Systemic deficiency of vitronectin is associated with aortic inflammation and plaque progression in ApoE‐Knockout mice
por: Chakravarty, Devasmita, et al.
Publicado: (2021)

Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases
por: Mrugacz, Małgorzata, et al.
Publicado: (2021)

The mouse vitronectin receptor is a T cell activation antigen
Publicado: (1991)

Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma
por: Burgos-Panadero, Rebeca, et al.
Publicado: (2019)

Vitronectin-based hydrogels recapitulate neuroblastoma growth conditions
por: Monferrer, Ezequiel, et al.
Publicado: (2022)

Inflammation of Dry Eye Syndrome: A Cellular Study of the Epithelial and Macrophagic Involvement of NFAT5 and RAGE
por: Henrioux, Fanny, et al.
Publicado: (2023)

Dysfunctional Coping Mechanisms Contribute to Dry Eye Symptoms
por: Patel, Sneh, et al.
Publicado: (2019)

The Effect of TNF-α Blocker HL036337 and Its Best Concentration to Inhibit Dry Eye Inflammation
por: Choi, Wungrak, et al.
Publicado: (2016)

HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease
por: Ji, Yong Woo, et al.
Publicado: (2020)

Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability
por: Chen, Pei-Hong, et al.
Publicado: (2008)

Keep Eyes on Integrins
por: Fan, Zhichao, et al.
Publicado: (2016)

Targeting purinergic receptors to attenuate inflammation of dry eye
por: Wang, Jia-Ning, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1p1f9ppgonb7sm2q2aoci7nmo2