Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers

α-Synuclein oligomers are thought to play an important role in the pathogenesis of dementia with Lewy bodies (DLB). There is no effective cure for DLB at present. Previously, we demonstrated that in APP- and tau-transgenic mice, oral or intranasal rifampicin reduced brain Aβ and tau oligomers and im...

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Detalles Bibliográficos
Autores principales: Umeda, Tomohiro, Hatanaka, Yukari, Sakai, Ayumi, Tomiyama, Takami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395129/
https://www.ncbi.nlm.nih.gov/pubmed/34445158
http://dx.doi.org/10.3390/ijms22168453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395129/
https://www.ncbi.nlm.nih.gov/pubmed/34445158
http://dx.doi.org/10.3390/ijms22168453

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