miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity

Huntington’s disease (HD) is an autosomal-dominant brain disorder caused by mutant huntingtin (mHtt). Although the detailed mechanisms remain unclear, the mutational expansion of polyglutamine in mHtt is proposed to induce protein aggregates and neuronal toxicity. Previous studies have shown that th...

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Detalles Bibliográficos
Autores principales: Chang, Ching-Chi, Tsou, Sing-Hua, Chen, Wei-Jen, Ho, Ying-Jui, Hung, Hui-Chih, Liu, Guang-Yaw, Singh, Sandeep Kumar, Li, Hsin-Hua, Lin, Chih-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395150/
https://www.ncbi.nlm.nih.gov/pubmed/34445125
http://dx.doi.org/10.3390/ijms22168424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395150/
https://www.ncbi.nlm.nih.gov/pubmed/34445125
http://dx.doi.org/10.3390/ijms22168424

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