Structural Basis of Inhibition of DCLK1 by Ruxolitinib

Given the functional attributes of Doublecortin-like kinase 1 (DCLK1) in tumor growth, invasion, metastasis, cell motility, and tumor stemness, it is emerging as a therapeutic target in gastrointestinal cancers. Although a series of specific or nonspecific ATP-competitive inhibitors were identified...

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Detalles Bibliográficos
Autores principales: Jang, Dong Man, Lim, Hyo Jin, Hahn, Hyunggu, Lee, Yeon, Kim, Hark Kyun, Kim, Hyoun Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395186/
https://www.ncbi.nlm.nih.gov/pubmed/34445192
http://dx.doi.org/10.3390/ijms22168488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395186/
https://www.ncbi.nlm.nih.gov/pubmed/34445192
http://dx.doi.org/10.3390/ijms22168488

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