Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α

Inhibition of pyruvate dehydrogenase kinase (PDK) emerged as a potential strategy for treatment of cancer and metabolic disorders. Dichloroacetate (DCA), a prototypical PDK inhibitor, reduces the abundance of some PDK isoenzymes. However, the underlying mechanisms are not fully characterized and may...

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Detalles Bibliográficos
Autores principales: Škorja Milić, Nives, Dolinar, Klemen, Miš, Katarina, Matkovič, Urška, Bizjak, Maruša, Pavlin, Mojca, Podbregar, Matej, Pirkmajer, Sergej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395311/
https://www.ncbi.nlm.nih.gov/pubmed/34445316
http://dx.doi.org/10.3390/ijms22168610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395311/
https://www.ncbi.nlm.nih.gov/pubmed/34445316
http://dx.doi.org/10.3390/ijms22168610

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