ABCB1 Does Not Require the Side-Chain Hydrogen-Bond Donors Gln(347), Gln(725), Gln(990) to Confer Cellular Resistance to the Anticancer Drug Taxol

The multidrug efflux transporter ABCB1 is clinically important for drug absorption and distribution and can be a determinant of chemotherapy failure. Recent structure data shows that three glutamines donate hydrogen bonds to coordinate taxol in the drug binding pocket. This is consistent with earlie...

Descripción completa

Detalles Bibliográficos
Autores principales: Sasitharan, Keerthana, Iqbal, Hamzah Asad, Bifsa, Foteini, Olszewska, Aleksandra, Linton, Kenneth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395328/
https://www.ncbi.nlm.nih.gov/pubmed/34445264
http://dx.doi.org/10.3390/ijms22168561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395328/
https://www.ncbi.nlm.nih.gov/pubmed/34445264
http://dx.doi.org/10.3390/ijms22168561

Ejemplares similares