Thrombin Inhibition Prevents Endothelial Dysfunction and Reverses 20-HETE Overproduction without Affecting Blood Pressure in Angiotensin II-Induced Hypertension in Mice

Angiotensin II (Ang II) induces hypertension and endothelial dysfunction, but the involvement of thrombin in these responses is not clear. Here, we assessed the effects of the inhibition of thrombin activity by dabigatran on Ang II-induced hypertension and endothelial dysfunction in mice with a part...

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Detalles Bibliográficos
Autores principales: Kij, Agnieszka, Bar, Anna, Przyborowski, Kamil, Proniewski, Bartosz, Mateuszuk, Lukasz, Jasztal, Agnieszka, Kieronska-Rudek, Anna, Marczyk, Brygida, Matyjaszczyk-Gwarda, Karolina, Tworzydlo, Anna, Enggaard, Camilla, Hansen, Pernille B. Lærkegaard, Jensen, Boye, Walczak, Maria, Chlopicki, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395447/
https://www.ncbi.nlm.nih.gov/pubmed/34445374
http://dx.doi.org/10.3390/ijms22168664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395447/
https://www.ncbi.nlm.nih.gov/pubmed/34445374
http://dx.doi.org/10.3390/ijms22168664

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