Tamoxifen Sensitizes Acute Lymphoblastic Leukemia Cells to Cannabidiol by Targeting Cyclophilin-D and Altering Mitochondrial Ca(2+) Homeostasis

Cytotoxic effects of cannabidiol (CBD) and tamoxifen (TAM) have been observed in several cancer types. We have recently shown that CBD primarily targets mitochondria, inducing a stable mitochondrial permeability transition pore (mPTP) and, consequently, the death of acute lymphoblastic leukemia (T-A...

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Detalles Bibliográficos
Autores principales: Olivas-Aguirre, Miguel, Torres-López, Liliana, Gómez-Sandoval, Zeferino, Villatoro-Gómez, Kathya, Pottosin, Igor, Dobrovinskaya, Oxana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395529/
https://www.ncbi.nlm.nih.gov/pubmed/34445394
http://dx.doi.org/10.3390/ijms22168688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395529/
https://www.ncbi.nlm.nih.gov/pubmed/34445394
http://dx.doi.org/10.3390/ijms22168688

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