Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is activated by the small G-protein, Ras homolog enriched in brain (RHEB–GTPase). On lysosome, RHEB activates mTORC1 by binding the domains of N-heat, M-heat, and the focal adhesion targeting (FAT) domain, which allosterically regulate...

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Detalles Bibliográficos
Autores principales: Shams, Raef, Ito, Yoshihiro, Miyatake, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395731/
https://www.ncbi.nlm.nih.gov/pubmed/34445471
http://dx.doi.org/10.3390/ijms22168766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395731/
https://www.ncbi.nlm.nih.gov/pubmed/34445471
http://dx.doi.org/10.3390/ijms22168766

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