Insulin Receptor Isoforms Differently Regulate Cell Proliferation and Apoptosis in the Ligand-Occupied and Unoccupied State

The insulin receptor (IR) presents two isoforms (IR-A and IR-B) that differ for the α-subunit C-terminal. Both isoforms are expressed in all human cells albeit in different proportions, yet their functional properties-when bound or unbound to insulin-are not well characterized. From a cell model dep...

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Detalles Bibliográficos
Autores principales: Massimino, Michele, Sciacca, Laura, Parrinello, Nunziatina Laura, Scalisi, Nunzio Massimo, Belfiore, Antonino, Vigneri, Riccardo, Vigneri, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395753/
https://www.ncbi.nlm.nih.gov/pubmed/34445431
http://dx.doi.org/10.3390/ijms22168729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395753/
https://www.ncbi.nlm.nih.gov/pubmed/34445431
http://dx.doi.org/10.3390/ijms22168729

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